Journal article
Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: Pooled analysis of individual data from 10 international studies
D Zhu, HF Chung, AJ Dobson, N Pandeya, EJ Brunner, D Kuh, DC Greenwood, R Hardy, JE Cade, GG Giles, F Bruinsma, P Demakakos, MK Simonsen, S Sandin, E Weiderpass, GD Mishra
Human Reproduction | OXFORD UNIV PRESS | Published : 2020
Abstract
STUDY QUESTION: How does the risk of cardiovascular disease (CVD) vary with type and age of menopause? SUMMARY ANSWER: Earlier surgical menopause (e.g. <45 years) poses additional increased risk of incident CVD events, compared to women with natural menopause at the same age, and HRT use reduced the risk of CVD in women with early surgical menopause. WHAT IS KNOWN ALREADY: Earlier age at menopause has been linked to an increased risk of CVD mortality and all-cause mortality, but the extent that this risk of CVD varies by type of menopause and the role of postmenopausal HRT use in reducing this risk is unclear. STUDY DESIGN, SIZE, DURATION: Pooled individual-level data of 203 767 postmenopaus..
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Grants
Awarded by National Institute on Aging
Funding Acknowledgements
InterLACE project is funded by the Australian National Health and Medical Research Council project grant (APP1027196). GDM is supported by Australian National Health and Medical Research Council Principal Research Fellowship (APP1121844). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.